Genetic screening of FMF in
نویسندگان
چکیده
inherited inflammatory disease that is principally recognized in Jewish, Armenian, Turkish and Arab populations.1 The characteristic intermittent clinical episodes of fever, peritonitis, pleurisy, rashes and arthritis are variable in their pattern, frequency, intensity and age of onset, as is the proportion of FMF patients in different ethnic groups who develop amyloidosis A (AA).2 Since the release of chemotactic factors is one of the early events in an inflammatory response, therefore a defective inhibitor of these factors represent a highly susceptible target that can explain the observed clinical signs of the disease. Accordingly, a serine protease that inactivate complement component number 5a (C5a) and interleukin-8 was F
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